Role of furins in the maturation of the Spike protein of CoV-2-SARS: Evaluation of the antiviral potential of furin inhibitors | Pandemic PACT Tracker

Key facts

Disease
COVID-19
Start & end year
N/A
Known Financial Commitments (USD)
$0
Funder
INSERM, REACTing
Principal Investigator
B Coutard
Research Location
France
Lead Research Institution
Aix-Marseille Université
Research Priority Alignment
N/A

Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen morphology, shedding & natural history
Special Interest Tags
N/A
Study Type
Unspecified
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified

Abstract

Role of furins in the maturation of the Spike protein of CoV-2-SARS: Evaluation of the antiviral potential of furin inhibitors

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Last Updated:6 days ago

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Gut microbial trimethylamine N-oxide generation promotes risk of atrial fibrillation via muscarinic receptor-mediated autonomic dysfunction.

Authors
Arjunan S, Pemberton I, Li XS, Sangwan N, Akino L, Opoku E, Verbovetskiy D, Nemet I, Kim HS, Masumiya H, Wang Z, Lupica JA, Tian MY, Mao K, Mallela DP, Mohan M, Schumacher S, Rennison JH, Prasad S, Laurita KR, Chodisetty V, Chung MK, Van Wagoner DR, Barnard J, Smith JD, Wazni O, Hazen SL, Koeth RA.
Publish Year
2026
Journal
The Journal of clinical investigation
DOI
10.1172/jci201684

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