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In vitro and in silico reconstruction of VIDOCreplicating machinery-19 : Fundamentals for Antiviral Identification

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    INSERM, REACTing

  • Principal Investigator

    Isabelle Imbert

  • Research Location

    France

  • Lead Research Institution

    POLYTECH AFMB ARCHITECTURE ET FONCTION DES MACROMOLECULES BIOLOGIQUES

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    Digital Health

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

An interdisciplinary project that combines methods in artificial intelligence with protein biochemistry. Aims to (1) reconstitute, in vitro, the replication complex of COVID-19; (2) model it in silico; and finally (3) test nucleotide analogue type inhibitors (active on other viruses) and protein type inhibitors (nanobodies) that will target protein/protein interactions. This project will lay the groundwork for a future programme that will then integrate the structural aspects of this multi-enzyme complex of COVID-19.