In vitro and in silico reconstruction of VIDOCreplicating machinery-19 : Fundamentals for Antiviral Identification
- Funded by INSERM, REACTing
- Total publications:0 publications
Grant number: unknown
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Key facts
Disease
COVID-19Funder
INSERM, REACTingPrincipal Investigator
Isabelle ImbertResearch Location
FranceLead Research Institution
POLYTECH AFMB ARCHITECTURE ET FONCTION DES MACROMOLECULES BIOLOGIQUESResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen morphology, shedding & natural history
Special Interest Tags
Digital Health
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
An interdisciplinary project that combines methods in artificial intelligence with protein biochemistry. Aims to (1) reconstitute, in vitro, the replication complex of COVID-19; (2) model it in silico; and finally (3) test nucleotide analogue type inhibitors (active on other viruses) and protein type inhibitors (nanobodies) that will target protein/protein interactions. This project will lay the groundwork for a future programme that will then integrate the structural aspects of this multi-enzyme complex of COVID-19.