Targeting genetic and chemical vulnerabilities of novel coronavirus SARS-CoV-2 [Added supplement: COVID-19 Variant Supplement]

  • Funded by Canadian Institutes of Health Research (CIHR)
  • Total publications:0 publications

Grant number: 170658, 175510

Grant search

Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2022
  • Known Financial Commitments (USD)

    $727,392.8
  • Funder

    Canadian Institutes of Health Research (CIHR)
  • Principle Investigator

    Pending
  • Research Location

    Canada, Americas
  • Lead Research Institution

    McMaster University
  • Research Category

    Therapeutics research, development and implementation

  • Research Subcategory

    Pre-clinical studies

  • Special Interest Tags

    Gender

  • Study Subject

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The recent outbreak of the SARS-CoV-2 coronavirus in China and its continued international spread threatens to become a global pandemic. Although coronaviruses generally cause mild respiratory infections in humans, over the past 18 years, three animal-derived coronaviruses have emerged that cause much more severe disease: SARS-CoV, MERS-CoV, and the current SARS-CoV-2. Each of these emergent viruses cause substantially higher death rates than common coronavirus infections; the current estimate of the death rate due to COVID-19 syndrome caused by SARS-CoV-2 infection is ~2.5%. The main challenge in addressing these new coronavirus-associated outbreaks is a lack of suitable therapeutics to treat active disease (i.e., anti-viral drugs) or to prevent disease (i.e., appropriate vaccines). We propose to apply genomics-based tools and drug-screening platforms to rapidly pinpoint new targets for SARS-CoV-2 anti-viral agents and to identify candidate therapeutic compounds. Our team has deep expertise in anti-infective drug discovery, the application of genomics in identifying drug targets, and in the biology and biochemistry of RNA viruses such as SARS-CoV-2. Our project will identify new therapeutic strategies that may help to treat COVID-19 patients. These strategies will also help mitigate newly emergent coronavirus-associated diseases that will undoubtedly continue to cause outbreaks in the future.