MRC Centre for Virus Research (MRC CVR) - COVID-19

Key facts

Disease
COVID-19
Start & end year
2020
2020
Known Financial Commitments (USD)
$660,260
Funder
UK Research and Innovation (UKRI)
Principal Investigator
Prof. Massimo Palmarini
Research Location
United Kingdom
Lead Research Institution
MRC - University of Glasgow Centre for Virus Research (CVR)
Research Priority Alignment
N/A

Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen genomics, mutations and adaptations
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable

Abstract

This award is being made in recognition that key Centre staff have been redeployed from their usual work, and Centre resources utilised, to contribute to the first phase of a rapid research response to the COVID-19 pandemic. The MRC Centre for Virus Research at the University of Glasgow (CVR) represents the UK's largest grouping of human and veterinary virologists. The Centre has contributed expertise to recent Ebola outbreaks, and is now working on SARS-CoV2 with £0.5m of supplementary funding. Working in collaboration with the NHS Greater Glasgow & Clyde West of Scotland Specialist Virology Centre, CVR researchers completed the genomic sequencing and analysis of Scotland's first confirmed Covid-19 case within 48 hours of diagnosis.

Publicationslinked via Europe PMC

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Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants.

Serological and Molecular Investigation of SARS-CoV-2 in Horses and Cattle in Switzerland from 2020 to 2022.

Event rates and incidence of post-COVID-19 condition in hospitalised SARS-CoV-2 positive children and young people and controls across different pandemic waves: exposure-stratified prospective cohort study in Moscow (StopCOVID).

Authors
Pazukhina E, Rumyantsev M, Baimukhambetova D, Bondarenko E, Markina N, El-Taravi Y, Petrova P, Ezhova A, Andreeva M, Iakovleva E, Bobkova P, Pikuza M, Trefilova A, Abdeeva E, Galiautdinova A, Filippova Y, Bairashevskaia A, Zolotarev A, Bulanov N, DunnGalvin A, Chernyavskaya A, Kondrikova E, Kolotilina A, Gadetskaya S, Ivanova YV, Turina I, Eremeeva A, Fedorova LA, Comberiati P, Peroni DG, Nekliudov N, Genuneit J, Reyes LF, Brackel CLH, Mazankova L, Miroshina A, Samitova E, Borzakova S, Carson G, Sigfrid L, Scott JT, McFarland S, Greenhawt M, Buonsenso D, Semple MG, Warner JO, Olliaro P, Osmanov IM, Korsunskiy AA, Munblit D, Sechenov StopCOVID Research Team.
Publish Year
2024
Journal
BMC medicine
DOI
10.1186/s12916-023-03221-x

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Prevalence of Endemic Respiratory Viruses During the COVID-19 Pandemic in Urban and Rural Malawi.

Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infection.

Resurrection of 2'-5'-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication.

Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning.

Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera.

SARS-CoV-2 variants evolve convergent strategies to remodel the host response.

Authors
Bouhaddou M, Reuschl AK, Polacco BJ, Thorne LG, Ummadi MR, Ye C, Rosales R, Pelin A, Batra J, Jang GM, Xu J, Moen JM, Richards AL, Zhou Y, Harjai B, Stevenson E, Rojc A, Ragazzini R, Whelan MVX, Furnon W, De Lorenzo G, Cowton V, Syed AM, Ciling A, Deutsch N, Pirak D, Dowgier G, Mesner D, Turner JL, McGovern BL, Rodriguez ML, Leiva-Rebollo R, Dunham AS, Zhong X, Eckhardt M, Fossati A, Liotta NF, Kehrer T, Cupic A, Rutkowska M, Mena I, Aslam S, Hoffert A, Foussard H, Olwal CO, Huang W, Zwaka T, Pham J, Lyons M, Donohue L, Griffin A, Nugent R, Holden K, Deans R, Aviles P, Lopez-Martin JA, Jimeno JM, Obernier K, Fabius JM, Soucheray M, Hüttenhain R, Jungreis I, Kellis M, Echeverria I, Verba K, Bonfanti P, Beltrao P, Sharan R, Doudna JA, Martinez-Sobrido L, Patel AH, Palmarini M, Miorin L, White K, Swaney DL, Garcia-Sastre A, Jolly C, Zuliani-Alvarez L, Towers GJ, Krogan NJ.
Publish Year
2023
Journal
Cell
DOI
10.1016/j.cell.2023.08.026

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