MRC Centre for Virus Research (MRC CVR) - COVID-19

Grant number: MC_PC_19026

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2020
  • Known Financial Commitments (USD)

    $660,260
  • Funder

    UK Research and Innovation (UKRI)
  • Principal Investigator

    Prof. Massimo Palmarini
  • Research Location

    United Kingdom
  • Lead Research Institution

    MRC - University of Glasgow Centre for Virus Research (CVR)
  • Research Priority Alignment

    N/A
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen genomics, mutations and adaptations

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

This award is being made in recognition that key Centre staff have been redeployed from their usual work, and Centre resources utilised, to contribute to the first phase of a rapid research response to the COVID-19 pandemic. The MRC Centre for Virus Research at the University of Glasgow (CVR) represents the UK's largest grouping of human and veterinary virologists. The Centre has contributed expertise to recent Ebola outbreaks, and is now working on SARS-CoV2 with £0.5m of supplementary funding. Working in collaboration with the NHS Greater Glasgow & Clyde West of Scotland Specialist Virology Centre, CVR researchers completed the genomic sequencing and analysis of Scotland's first confirmed Covid-19 case within 48 hours of diagnosis.

Publicationslinked via Europe PMC

Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants.

Event rates and incidence of post-COVID-19 condition in hospitalised SARS-CoV-2 positive children and young people and controls across different pandemic waves: exposure-stratified prospective cohort study in Moscow (StopCOVID).

Serological and Molecular Investigation of SARS-CoV-2 in Horses and Cattle in Switzerland from 2020 to 2022.

Prevalence of Endemic Respiratory Viruses During the COVID-19 Pandemic in Urban and Rural Malawi.

Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infection.

Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning.

Resurrection of 2'-5'-oligoadenylate synthetase 1 (OAS1) from the ancestor of modern horseshoe bats blocks SARS-CoV-2 replication.

SARS-CoV-2 variants evolve convergent strategies to remodel the host response.

SARS-CoV-2 in Domestic UK Cats from Alpha to Omicron: Swab Surveillance and Case Reports.