Healthcare Workers: an in depth virological analysis and behavioural study during the outbreak

  • Funded by Department of Health and Social Care / National Institute for Health and Care Research (DHSC-NIHR), UK Research and Innovation (UKRI)
  • Total publications:12 publications

Grant number: MC_PC_19082

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2022
  • Known Financial Commitments (USD)

    $1,829,738.75
  • Funder

    Department of Health and Social Care / National Institute for Health and Care Research (DHSC-NIHR), UK Research and Innovation (UKRI)
  • Principle Investigator

    Pending
  • Research Location

    United Kingdom, Europe
  • Lead Research Institution

    University College London
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    Gender

  • Study Subject

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Adults (18 and older)

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Health PersonnelHospital personnelNurses and Nursing StaffPhysicians

Abstract

This COVID-19 Rapid Response award is jointly funded (50:50) between the Medical Research Council and the National Institute for Health Research. The figure displayed is the total award amount of the two funders combined, with each partner contributing equally towards the project. The further spread of the novel coronavirus SARS-CoV-2 outside China, causing coronavirus disease (COVID-19) globally has led to an outbreak that WHO announced 12 March 2020 as a pandemic. The role of Healthcare Workers (HCWs) in managing the outbreak is critical, while working in a setting where they may be inadvertently exposed to SARS-CoV-2, and WHO has prioritised research on how best to protect them from infection and disease. The similar "Public Health Emergencies of International Concern" caused by Zika and Ebola highlighted another important aspect: the need to integrate social sciences research into the outbreak response and to address ethical questions around studies and data sharing, in this context involving HCWs. With our proposal, we aim to integrate three key priorities in a unique way. We will leverage existing funding and our experience within the ICONIC study, funded by the Wellcome Trust/DoH (2014-18). We propose an in-depth analysis of risk of infection with SARS-CoV-2 in HCWs including longitudinal sampling, tracking of movement and studies of behaviours and influences on them (capability, opportunity and motivation). We will perform a virological analysis of infected patients with serial samples to construct a detailed analysis of transmission clusters. The latter will provide valuable clinical data on virus shedding. Finally, we propose to address the ethical questions around the use of apps and wearables, data sharing and conducting studies during an outbreak to produce a set of definitive recommendations for policy makers.

Publicationslinked via Europe PMC

Last Updated:41 minutes ago

View all publications at Europe PMC

Factors influencing uptake of protective behaviours by healthcare workers in England during the COVID-19 pandemic: A theory-based mixed-methods study.

Assessing spatiotemporal variability in SARS-CoV-2 infection risk for hospital workers using routinely-collected data.

Investigating healthcare worker mobility and patient contacts within a UK hospital during the COVID-19 pandemic.

Detection of SARS-CoV-2 infection by saliva and nasopharyngeal sampling in frontline healthcare workers: An observational cohort study.

Serological profile of first SARS-CoV-2 reinfection cases detected within the SIREN study.

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains.

The effect of spike mutations on SARS-CoV-2 neutralization.

Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections.

Nosocomial Transmission of Coronavirus Disease 2019: A Retrospective Study of 66 Hospital-acquired Cases in a London Teaching Hospital.