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Profiling SARS-CoV-2 intra-viral and virus-host interactions on the basis of innate immunity signaling (PSII project)

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:0 publications

Grant number: PSII

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Key facts

  • Disease

    COVID-19

  • Funder

    Institut Pasteur International Network (IPIN)

  • Principal Investigator

    Pending

  • Research Location

    France

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Aim: the coronavirus replication cycle depends on several protein-protein interactions, some between viral proteins to generate functional protein complexes and others with host proteins to inhibit the innate immune response. Identifying these interactions, which are essential for viral infection, can reveal the molecular mechanisms involved in pathogenesis and identify weak points in the virus that may be potential therapeutic targets.