Working towards controlled detection of SARS-CoV-2 by the innate immune system (CoV-2Sensing project)
- Funded by Institut Pasteur International Network (IPIN)
- Total publications:0 publications
Grant number: CoV-2Sensing
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Key facts
Disease
COVID-19Funder
Institut Pasteur International Network (IPIN)Principal Investigator
N/A
Research Location
FranceLead Research Institution
N/AResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Immunity
Special Interest Tags
N/A
Study Type
Unspecified
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified
Abstract
Aim: controlling the SARS-CoV-2 outbreak requires both scientific knowledge and antiviral drugs. RIG-I-like receptors in the cell cytoplasm play a major role in detecting infection with RNA viruses and in initiating and modulating antiviral immunity. The aim of the project is to study the RNA ligands in the SARS-CoV-2 virus that are detected by these receptors. The project will shed light on the innate immune response to SARS-CoV-2, including the harmful effects of the immune response, thereby helping identify strategies for the design of broad-spectrum antiviral drugs and vaccine adjuvants.