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Production of recombinant antigens from two SARS-CoV-2 proteins and generation of nano-antibodies against these proteins for diagnostic and therapeutic applications (CORONABODIES project)

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:0 publications

Grant number: CORONABODIES

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Key facts

  • Disease

    COVID-19

  • Funder

    Institut Pasteur International Network (IPIN)

  • Principal Investigator

    .

  • Research Location

    France

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Diagnostics

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Aim: to develop reliable rapid diagnostic tests for the infection that can be performed in a few minutes, anywhere and at any time, outside research laboratories; and serological tests to monitor the spread of the outbreak virtually in real time, helping with the implementation of mitigation measures.The idea is to generate the following unique tools as quickly as possible:recombinant SARS-CoV-2 nucleoprotein (N) and spike (S) antigens;nano-antibodies targeting these two proteins. These tools will be used to develop: serological tests for a serological survey of the exposed population, to help sort suspected cases and enable real-time monitoring of the spread of the outbreak;antigen detection tests that can be used for quick and effective sorting of suspected cases.Neutralization of the virus with "anti-S" nanobodies will also provide direct options for clinical therapeutic development.