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A combination of cutting-edge proteomic approaches for improving understanding of SARS-CoV-2 infection mechanisms (PROTEO-SARS-CoV-2 project)

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:3 publications

Grant number: PROTEO-SARS-CoV-2

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Funder

    Institut Pasteur International Network (IPIN)

  • Research Location

    France

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Aim: to characterize the cellular mechanisms of SARS-CoV-2 infection. Using several cutting-edge mass spectrometry protein analysis techniques, the team is seeking to understand how the virus interacts with human cells. They are particularly interested in cellular mechanisms that enable the virus to modify proteins in infected cells in order to reproduce. This study conducted in tandem with a comparison with other viruses from the coronavirus family may enable new therapeutic targets to be identified.

3 Publications linked via Europe PMC

Last Updated:6 days ago

View all publications at Europe PMC

The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 Variants.

Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies.

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies.