Generation of animal models sensitive to SARS-CoV-2 to test vaccines or drugs (hACE2-COV project)
- Funded by Institut Pasteur International Network (IPIN)
- Total publications:0 publications
Grant number: hACE2-COV
Grant search
Key facts
Disease
COVID-19Funder
Institut Pasteur International Network (IPIN)Principal Investigator
N/A
Research Location
FranceLead Research Institution
N/AResearch Priority Alignment
N/A
Research Category
Therapeutics research, development and implementation
Research Subcategory
Pre-clinical studies
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
Aim - Rapid development of animal models is of utmost importance to test the efficacy of vaccines and drug against COVID-19. The aim of this research project is to propose models whose cells express the human ACE2 proteins (huACE2) so that they are sensitive to SARS-CoV-2. The ACE2 protein is the gateway for the virus to enter cells. Researchers are proposing to use adenoviruses and lentiviruses as a vector to introduce the huACE2 gene.