Re-positioning of drug-discovery approaches to develop point-of-care diagnostic tests for COVID-19

Grant number: COV/ABN/20/01

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Key facts

  • Disease

    COVID-19
  • Known Financial Commitments (USD)

    $277,358.24
  • Funder

    CSO Scotland
  • Principal Investigator

    Prof. Andy Porter
  • Research Location

    United Kingdom
  • Lead Research Institution

    University of Aberdeen
  • Research Priority Alignment

    N/A
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Diagnostics

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Diagnostic testing for Covid-19 uses gold-standard laboratory testing. However, protocols are complex, need centralised laboratories, take 4-6 hours to complete and require shipment of clinical samples. Tests that can be done in-situ/in the community (known as "point-of-care" (PoC) tests) are urgently needed to speed up clinical decision-making and reduce the workload of test laboratories. In this project, we propose to re-position drug-discovery methods that have already revolutionised cancer therapy to develop new PoC diagnostic tests to deliver pregnancy-like test results in 30 minutes.

Publicationslinked via Europe PMC

Last Updated:14 hours ago

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Monoclonal Human Antibodies That Recognise the Exposed N and C Terminal Regions of the Often-Overlooked SARS-CoV-2 ORF3a Transmembrane Protein.

Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography.