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Host biomarkers of acute respiratory distress syndrome in Covid-19 infection

Grant number: COV/DUN/20/01

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Known Financial Commitments (USD)

    $364,426.08

  • Funder

    CSO Scotland

  • Principal Investigator

    Prof. Doreen Cantrell

  • Research Location

    United Kingdom

  • Lead Research Institution

    University of Dundee

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Diagnostics

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

The objective is to identify tests that can identify early in COVID19 infection which patients are at risk of worsening and needing intensive care treatment. We will look in the white blood cells of COVID19 patients and used advanced proteomic technology to find new diagnostic tools. The work will also identify new drug targets for the treatment of acute respiratory distress syndrome.

5 Publications linked via Europe PMC

Last Updated:2 days ago

View all publications at Europe PMC

Extensive acute and sustained changes to neutrophil proteomes post-SARS-CoV-2 infection.

Extracellular vesicles in COVID-19 convalescence can regulate T cell metabolism and function.

Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19.

Supporting doctors' well-being and resilience during COVID-19: A framework for rapid and rigorous intervention development.

­­­­­­­A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS­­­