Domestic animals as potential vectors for SARS-CoV-2 transmission

  • Funded by Bundesministerium für Bildung und Forschung [German Federal Ministry of Education and Research] (BMBF)
  • Total publications:3 publications

Grant number: 01KI2074A

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2021
  • Known Financial Commitments (USD)

    $89,256.79
  • Funder

    Bundesministerium für Bildung und Forschung [German Federal Ministry of Education and Research] (BMBF)
  • Principle Investigator

    Pending
  • Research Location

    Germany, Europe
  • Lead Research Institution

    Deutsches Primaten Zentrum, Göttingen
  • Research Category

    Animal and environmental research and research on diseases vectors

  • Research Subcategory

    Animal source and routes of transmission

  • Special Interest Tags

    Gender

  • Study Subject

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Abstract: "The recent emergence and the rapid pandemic spread of SARS-CoV-2 pose a global health emergency. The origin of the virus has not been fully investigated so far. It is assumed that horseshoe bats harboring progeny coronaviruses serve as the natural reservoir host, while pangolins may serve as intermediate host. However, information on potential permissive animal species is largely lacking. Given the frequent and close contact between humans and domestic animals, is it important to elucidate whether animals such as dogs, cats or ferrets and livestock, especially cattle and pigs, are susceptible to SARS-CoV-2 infection and might promote viral dissemination among animals and humans. Indeed, there is already circumstantial evidence that dogs might become infected by SARS-CoV-2. Therefore, this project will employ primary cells obtained from the upper and lower respiratory tract of a variety of domestic animals to determine permissiveness to SARS-CoV-2 infection. Studies will include mode of entry and spread and pathogenetic mechanisms using molecular and microscopic analyses. The results will facilitate risk assessment and prevention of potential interspecies transmission."; Research Type: discovery; Study population: domestic animals (cats, dogs) and farm animals (bovine animals, pigs)

Publicationslinked via Europe PMC

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View all publications at Europe PMC

Evidence for an ACE2-Independent Entry Pathway That Can Protect from Neutralization by an Antibody Used for COVID-19 Therapy.

The Upper Respiratory Tract of Felids Is Highly Susceptible to SARS-CoV-2 Infection.

SARS-CoV-2 variant B.1.617 is resistant to bamlanivimab and evades antibodies induced by infection and vaccination.