Human alveolar barrier damage in COVID 19 associated lung failure

Abstract: The aim of the project is to investigate whether the body's own substances are responsible for the damage to the lung tissue in COVID-19 patients who suffer from the so-called "Acute Respiratory Distress Syndrome" (ARDS). The investigation is to be carried out in the laboratory on lung cells. In addition, the aim is to investigate whether the suspected mechanism of action that triggers ARDS can be inhibited by an active ingredient that has already been tested in clinical studies for other indications. In the short to medium term, such studies could provide important insights for the treatment of severe cases of COVID-19. If the project is successful, a starting point for the development of a therapeutic agent could be identified in the medium to long term.; Research Type: discovery; Study population: not applicable