Population-based survey of SARS-CoV-2 infection and immune response

To have an optimal response to the COVID-19 epidemic, it is important to understand the proportion of adultsin the United States may have the virus that causes COVID-19, and how many have had it in the past and mayhave immunity. Currently available data are limited because the impact of asymptomatic and mildlysymptomatic cases is unclear and many people are unable to access a test due to rationing, or may beotherwise unwilling to go for testing or care. This study will address this problem by conducting a nationalprobability sample, where each address may be selected by chance, to develop estimates of the proportion ofadults in the United States that are infected with the virus that causes COVID-19, and the proportion that hashad the disease in the past and may now have immunity. We will use home-based testing techniques tofacilitate participation in this national study. We will also use surveys to better understand participants in oursample. With these estimates, we will conduct disease modeling to understand different scenarios of theepidemic. We will also develop a website to provide information and data to the public.