Microbial, immune, metabolic perturbations by antibiotics (MIME study)

  • Funded by National Institutes of Health (NIH)
  • Total publications:5 publications

Grant number: 3U01AI122285-05S1

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2021
  • Known Financial Commitments (USD)

    $1,558,030
  • Funder

    National Institutes of Health (NIH)
  • Principle Investigator

    Pending
  • Research Location

    United States of America, Americas
  • Lead Research Institution

    Rutgers The State University of New Jersey
  • Research Category

    Epidemiological studies

  • Research Subcategory

    Disease transmission dynamics

  • Special Interest Tags

    Gender

  • Study Subject

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Adults (18 and older)

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Health PersonnelHospital personnel

Abstract

As SARS-CoV-2 is sweeping through the USA, healthcare workers (HCW) are our first line ofdefense. But they too are susceptible to becoming infected, resulting in physical illness, loss ofproductivity, and potential for disease transmission to patients. Our long-term goal is to protectHCW taking care of SARS-CoV-2-infected patients as well as their families, communities, andthe general population. Our specific objective is to rapidly establish a prospective cohort tocharacterize the factors related to viral transmission and disease severity in a large healthcaresystem in both healthcare settings and workers' households. Our central hypothesis is thatHCW are at higher risk of acquiring and transmitting SARS-CoV-2 and COVID-19 comparedwith non-healthcare workers (NCHW). We propose to address this hypothesis by recruiting andfollowing 500 HCW and 250 age- and sex-matched NHCW within a large academic healthsystem, Rutgers Biomedical and Health Sciences (RBHS). By intensively following participantsover a six-month period and collecting serial biospecimens (nasopharyngeal swabs and blood)and questionnaire data at nine time points, we will be uniquely situated to characterize SARS-CoV-2 transmission and risk factors for COVID-19 among HCW and their families. Our specificaims are: (i), to assess the baseline prevalence of SARS-CoV-2 and COVID-19 in the studypopulation; (ii), to characterize the natural history of SARS-CoV-2 infection in a diverse USworkforce, including the incidence of asymptomatic infections and critical illness; (iii), todetermine the incidence of SARS-CoV-2 and COVID-19 in healthcare workers compared withnon-healthcare workers; (iv), to identify the risk factors for acquiring SARS-CoV-2 anddeveloping COVID-19; (v), to determine the duration and extent of SARS-CoV-2 shedding; and(vi), to determine the rate and direction of transmission of SARS-CoV-2 within households. Ourmultidisciplinary team has the opportunity, population, resources, and motivation to immediatelytackle these crucial questions and to mobilize in the early stages of this public health crisisbefore overwhelming infection occurs in the US. The proposed cohort study will produceimmediate, actionable, and translatable knowledge about protecting the healthcare workforce.The established cohort and repository of ~15,000 biospecimens will also serve as a foundationfor future mechanistic studies. The coordinated activities of our team working within a largehealthcare system will advance efforts to control, treat, and prevent COVID-19, with focus onthe safety of HCW and the staffing of hospitals during this continuing epidemic.

Publicationslinked via Europe PMC

Last Updated:40 minutes ago

View all publications at Europe PMC

Determinants and Dynamics of SARS-CoV-2 Infection in a Diverse Population: 6-Month Evaluation of a Prospective Cohort Study.

Recurrence of Upper Extremity Deep Vein Thrombosis Secondary to COVID-19.

Risk Factors for Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Hospital Workers: Results From a Screening Study in New Jersey, United States in Spring 2020.

COVID-19 as a Trigger of Recurrent Guillain-Barré Syndrome.

Prevalence of SARS-CoV-2 infection in previously undiagnosed health care workers in New Jersey, at the onset of the U.S. COVID-19 pandemic.