Immunophenotyping for COVID-19 Cohort (IMPACC)

In depth immunoprofiling of COVID-19 patients will be established to identify critical elements ofthe immune responses to the corona virus SARS-Co-V-2. This study is part of the IMPACCstudy group formed to conduct in depth analyses of samples from COVID-19 patients. Sharedprotocols for subject enrollment and sample collection have been established by the IMPACCstudy group to be collected across key time points of the disease. Our analysis will includebroad phenotyping of cell subsets and transcriptional responses of critical patient samples.Results will be assessed with the IMPACC study group bioinformatics team for integration withresults from IMPACC core facilities on the same samples such as bulk RNASeq, serumproteomics and metabolomics, DNA sequencing, and multiparameter single cell CyTOF ofendotracheal aspirates. Our studies to clarify and elucidate critical pathways in COVID-19pathogenesis and immune response will guide development of anti-viral therapeutics andvaccines to maximize resistance to the virus.