HIPC-COVID:Immunophenotyping Study - Supplement 1: HIPC - Clinical Sample Collection and Processing

Summary:The goal of the Administrative Supplement is to provide a central rich store of data and specimensfrom two independent cohorts located in Reading, Pennsylvania and Cleveland, Ohio. Thesamples and the clinical data will be distributed to the central cores assigned by the programwhere standardized phenotypic assays will be performed. General leadership of the Cores will beprovided by Dr. Charles Cairns from Drexel University for the Reading cohort and Dr. Benignofrom Case Western Reserve University.There are 3 aims of this Administrative supplement.Specific Aim 1: To provide biological specimens (PBMCs, sputum, and lavages) to all ourdesignated cores in order to characterize the immunophenotypes and the immune status andresponse to COVID-19 infection.Specific Aim 2: To provide clinical data (CBC counts, clinical tests, imaging) to all our designatedcores in order to establish correlation with immune status and disease progressionSpecific Aim 3: To provide biological specimens and clinical data to our assigned laboratories atDrexel and Case Western Universities. These laboratories will perform unique assays that are notcovered by the core laboratories of the program.