Functional and dysfunctional human CD4 T cell and B cell responses to bacteria and viruses

  • Funded by National Institutes of Health (NIH)
  • Total publications:0 publications

Grant number: 3U19AI142742-02S1

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2021
  • Known Financial Commitments (USD)

    $982,950
  • Funder

    National Institutes of Health (NIH)
  • Principle Investigator

    Pending
  • Research Location

    United States of America, Americas
  • Lead Research Institution

    LA JOLLA INSTITUTE FOR IMMUNOLOGY
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    Gender

  • Study Subject

    Clinical

  • Clinical Trial Details

    Unspecified

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

PROJECT SUMMARYOverall ComponentCOVID19 is a severe ongoing pandemic. Our understanding of the immune response to this disease is lacking,which impairs both the development of proper therapeutics and a vaccine. Vaccines are one of the most costeffective and extraordinarily successful medical interventions. Most of those vaccines depend on CD4 T+ cellsand their help to B cells. We have developed multiple new techniques to study human CD4+ T cells over the pastseveral years, which have have been implementing in our LJI CCHI. The supplement proposed here will facilitaterapid and vigorous pursuit of an understanding of the T cell responses to SARS-CoV2 in humans, which mayhelp in the development of treatments and vaccines for COVID19.