Nonhuman Primate Reagent Resource

U24 AI126683 - Parent Award AbstractNonhuman primates (NHPs) serve a crucial role in translational research as animal models for exploring thepathogenesis of infectious and noninfectious diseases, and for testing of biologic therapies and vaccines. Whilemany human diagnostic immunologic reagents cross react with the primate species commonly employed intranslational research, gaps exist for a substantial number of reagent targets. Furthermore, antibodies thattarget specific immune functions or deplete specific lymphocyte subpopulations in vivo have proven valuable indefining disease mechanisms or can be used as proof-of-concept for new therapies.For the past 15 years, the NIH Nonhuman Primate Reagent Resource has responded to needs of the scientificcommunity by developing, manufacturing and distributing NHP-specific reagents for in vitro diagnostics and forin vivo use. Utilization of this resource has grown dramatically since this program's inception. During the lastbudget year, we fulfilled 500 reagent requests from 126 investigators and distributed over 300 grams ofrecombinant antibody for administration to NHPs.Taking advantage of scientific advances and technological improvements in antibody development, engineering,expression and vectoring, we will continue to support the scientific community utilizing NHP models across allscientific disciplines.