Recognition and control of virus infections | Pandemic PACT Tracker

Key facts

Disease
COVID-19
Start & end year
N/A
Known Financial Commitments (USD)
$3,638,696.72
Funder
UK Research and Innovation (UKRI)
Principal Investigator
Dr. P Beard
Research Location
United Kingdom
Lead Research Institution
The Pirbright Institute
Research Priority Alignment
N/A

Research Category
N/A
Research Subcategory
N/A
Special Interest Tags
N/A
Study Type
Unspecified
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified

Abstract

PI: Enhanced host responses for disease control: a BBSRC Strategic Programme

224 Publications linked via Europe PMC

Last Updated:4 days ago

View all publications at Europe PMC

Evaluation of the contribution of the minor envelope complex glycoprotein 3 ectodomain to the porcine reproductive and respiratory syndrome virus 1 neutralizing antibody response.

Induction of neutralising antibodies against conserved rhinovirus capsid protein VP4 is dependent on presentation of VP4 peptide immunogens in a virus-like conformation.

Profiling of porcine B-cell receptor heavy-chain repertoires indicates the development of a wide public pseudorabies virus-specific immune response after vaccination and challenge.

Nipah virus vaccines evaluated in pigs as a 'One Health' approach to protect public health.

Authors
McLean RK, Pedrera M, Thakur N, Elrefaey AME, Hodgson S, Lowther S, Reid T, Todd S, Rowe B, Bergfeld J, Trinidad L, Riddell S, Edwards S, Payne J, Barr J, Rye N, Bruce M, Poole T, Brown S, Dalziel T, Au G, Fisher M, Layton R, Lambe T, Chappell K, Isaacs A, Watterson D, Mourino M, Raue R, Shanta IS, Siddika A, Begum MN, Rahman S, Bhuyan AAM, Alam M, Rahman MZ, Rahman M, Tchilian E, Gilbert SC, Young P, Bailey D, Marsh GA, Graham SP.
Publish Year
2025
Journal
NPJ vaccines
DOI
10.1038/s41541-025-01212-y

View at Europe PMC

A centralised immunogen approach to develop a more broadly protective modified live porcine reproductive and respiratory syndrome virus 1 vaccine candidate.

Attenuated but not virulent pseudorabies virus activates porcine bone marrow-derived dendritic cells.

Proliferation makes a substantive contribution to the maintenance of airway resident memory T-cell subsets in young pigs.

Evaluation of population immunity against SARS-CoV-2 variants, EG.5.1, FY.4, BA.2.86, JN.1, JN.1.4, and KP.3.1.1 using samples from two health demographic surveillance systems in Kenya.

Authors
Lugano D, Kutima B, Kimani M, Sigilai A, Gitonga J, Karani A, Akech D, Karia B, Ziraba AK, Maina A, Lambisia A, Omuoyo D, Mugo D, Lucinde R, Owuor S, Konyino G, Newman J, Bailey D, Nduati E, Githinji G, Agoti CN, Bejon P, Scott JAG, Agweyu A, Kagucia W, Warimwe GM, Sande C, Ochola-Oyier LI, Nyagwange J.
Publish Year
2024
Journal
BMC infectious diseases
DOI
10.1186/s12879-024-10367-3

View at Europe PMC

A broadly reactive ultralong bovine antibody that can determine the integrity of foot-and-mouth disease virus capsids.