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Potential mechanisms of COVID-19 drug targets on other viral infection phenotypes and complex diseases

  • Funded by UK Research and Innovation (UKRI)
  • Total publications:0 publications

Grant number: C19-IUC-050

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Key facts

  • Disease

    COVID-19

  • Funder

    UK Research and Innovation (UKRI)

  • Principal Investigator

    Jie Zheng

  • Research Location

    United Kingdom

  • Lead Research Institution

    University of Bristol

  • Research Priority Alignment

    N/A

  • Research Category

    Therapeutics research, development and implementation

  • Research Subcategory

    Pre-clinical studies

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Project to identify genetic predictors of the potential drug targets for COVID-19 from 4 recently published GWASs, and use them as instruments to systematically assess the causal effects of 378 SARS-COV-2 interacted proteins / genes on 46 infection diseases and 576 complex human diseases in 5 related human tissues using Mendelian randomization (MR). Such analysis will help evaluate the causal consequences of these genes/proteins on complex human diseases. Results of all analyses are available in an open assess online platform (www.epigraphdb.org/covid19/drug-accelerator/) to enable rapid queries.