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Developing inhibitors against the crucial Nsp3 SARS-CoV-2 protease enzyme

  • Funded by UK Research and Innovation (UKRI)
  • Total publications:0 publications

Grant number: C19-IUC-109

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Key facts

  • Disease

    COVID-19

  • Funder

    UK Research and Innovation (UKRI)

  • Principal Investigator

    Yogesh Kulathu

  • Research Location

    United Kingdom

  • Lead Research Institution

    MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Characterise the papain-like cysteine protease encoded by SARS CoV2 (PLpro), that cleaves both viral polypeptide and also ubiquitin molecules from cellular targets to block viral immune responses. Structure and function analysis is being performed in order to develop inhibitors to the enzyme in collaboration with the Dundee Drug Discovery Unit.