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Devising new methods to detect and visualize SARSCoV2 directly in infected human tissues

  • Funded by UK Research and Innovation (UKRI)
  • Total publications:0 publications

Grant number: C19-IUC-088

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Key facts

  • Disease

    COVID-19

  • Funder

    UK Research and Innovation (UKRI)

  • Principal Investigator

    Dr. John Le Quesne, Dr. James Thaventhiran, Prof. Marion MacFarlane

  • Research Location

    United Kingdom

  • Lead Research Institution

    MRC Toxicology Unit at the University of Cambridge

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

If immune cells (lymphocytes) are infected by this (SARS-CoV-2), then assumptions that patients previously infected are now immune may be incorrect. The project will devise new methods to detect and visualize SARS-CoV-2 directly in infected human tissues to determine which immune cells could be infected, which sub-class of two types of immune cells (T and B cells) are affected and which immune cells of the digestive tract may be affected. These methods will be able to confirm viral infection in deceased cases where a diagnosis was not made. _x005F_x005F_x005F_x005F_x005F_x005F_x005F_x000D_ _x005F_x005F_x005F_x005F_x005F_x005F_x005F_x000D_