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Cardiovascular response in COVID-19

  • Funded by UK Research and Innovation (UKRI)
  • Total publications:0 publications

Grant number: C19-IUC-082

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Key facts

  • Disease

    COVID-19

  • Funder

    UK Research and Innovation (UKRI)

  • Principal Investigator

    Sanjay Sinha

  • Research Location

    United Kingdom

  • Lead Research Institution

    Wellcome - Medical Research Council Cambridge Stem Cell Institute

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Cardiovascular dysfunction in COVID-19 will be investigated in vitro using human embryonic stem cell derived-cardiomyocyte and vascular cell models. Examining viral proteins and pseudotypes in to human cardiomyocytes and vascular cells and ways this can be modulated by modifying the ACE2 viral receptor or accessory proteases such as TMPRSS2. The project will also study the effects of the immune response on these cells.