New Branched Polymer Excipients and Emulsions for Enhanced Drug Delivery

This translational science research aims to build upon ongoing work across University of Liverpool and Liverpool School of Tropical medicine. The work aims to accelerate preclinical validation of drugs for Covid-19 treatment and/or prevention. To maximise healthcare impact, the work seeks to establish three direct outputs, namely; 1) Selection of candidates based on in vitro anti-SARS-CoV-2 activity, 2) Demonstration of In vivo pharmacokinetics and distribution supporting treatment and prevention applications, and 3) Demonstration of in vivo performance in mice infected with SARS-CoV-2. We expect the research to provide evidence-based candidates for evaluation in human clinical trials. We will also undertake additional evaluations for low-middle income settings, focussing on scalability and affordability in sub-Saharan Africa and preferring orally delivered medications, with little or no laboratory monitoring.