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Untersuchungen von molekularen SARS-CoV-2-Wirt-Interaktionen mit gezielten Knockouts und Pulldowns

  • Funded by Bundesministerium für Bildung und Forschung [German Federal Ministry of Education and Research] (BMBF)
  • Total publications:0 publications

Grant number: 01KI20393

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2020
    2021

  • Known Financial Commitments (USD)

    $90,173.89

  • Funder

    Bundesministerium für Bildung und Forschung [German Federal Ministry of Education and Research] (BMBF)

  • Principal Investigator

    Prof. Nikolaus Rajewsky

  • Research Location

    Germany

  • Lead Research Institution

    Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC)

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

discovery - This is a basic scientific research project on SARS-CoV-2. The aim of the project is to investigate in detail the mutual influences between the viruses and the metabolism of human host cells in a SARS-CoV-2 infection. Preliminary work has already identified certain ribonucleic acids (RNA) in the host cells, the expression of which is changed in the case of a SARS-CoV-2 infection. In the non-infected cell culture, this RNA should now be switched off (knockout) and the effects of an infection of the cells with the virus examined. Ultimately, possible new targets for pharmaceutical interventions against SARS-CoV-2 are to be found.