COREP: Determining the epidemiological parameters of COVID-19 through sero-surveillance with dried plasma spots and nested household transmission studies in rural Kenya and South Africa

Key facts

Disease
COVID-19
start year
2020
Known Financial Commitments (USD)
$594,125.35
Funder
European & Developing Countries Clinical Trials Partnership (EDCTP)
Principal Investigator
Pending
Research Location
Zambia
Lead Research Institution
Heidelberg University Hospital
Research Priority Alignment
N/A

Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Diagnostics
Special Interest Tags
N/A
Study Subject
Clinical
Clinical Trial Details
Not applicable
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Health Personnel

The COREP project (RIA2020EF-3026) aims to 1) define epidemiological parameters of SARS-CoV-2 infection in rural Kenya and South Africa, including the reproductive number, transmissibility, clinical disease spectrum and population-level incidence; 2) assess the burden of SARS-CoV-2 disease in rural areas of sub-Saharan Africa, and risk factors for infection and transmission; and 3) evaluate the diagnostic performance, feasibility, usability and cost-effectiveness of Dried Plasma Spot samples collected at the community level through fingerpricks by community health workers, followed by centralised serological testing.