Exploring immunologic and genetic factors in COVID-19 with relevance for immunity and long-term health; a new BAMSE follow-up (Immunologiska och genetiska faktorer vid COVID-19 av betydelse för immunitet och långsiktiga hälsoeffekter; en ny uppföljning av BAMSE-studien)

In this project, we propose a new COVID-19 focused follow-up of participants in our longitudinal BAMSE birth cohort (n=4,089 age 25-30 y) including repeated serology analyses of coronavirus immunity, risk factor assessment, elucidations of underlying genetic and immunologic factors and new lung function tests to evaluate long-term pulmonary effects.In Phase 1 (June-Jul 2020), a web survey on COVID-19 symptoms and lifestyle factors will be answered, and filter paper sent home for personal home blood sampling (collaboration with KTH). Analysis of SARS-CoV2 IgG will be done. In Phase 2 (Sept-Dec 2020), all participants will be invited to a clinical follow-up, including lung function meansurements and blood sampling and new web survey. Phase 3 (Jan - March 2021) will be the same as Phase 1.Linkage with national and regional health registers will be done. Immune phenotyping and analyses of cellular immunity will be explored. Large-scale proteomics data (OLINK) and Genome-wide genotype (GWAS) data are available for analyses; new whole genome sequencing, transcriptomics, epigenomic and proteomic analyses are planned. Lung function and BMI trajectories have been analyzed from childhood to adulthood.In the population-based BAMSE study, we have a unique opportunity in this project to study how SARS-Cov2 immunity develops in young adults, and thanks to our rich, longitudinal database and biobank, to evaluate key risk factors and health effects consequences of coronavirus infection. Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi