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Phosphorylation-dependent regulation of the RNA metabolism in the host response to coronavirus infection

Grant number: 197785619

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Key facts

  • Disease

    COVID-19

  • start year

    2013

  • Known Financial Commitments (USD)

    $0

  • Funder

    DFG

  • Principal Investigator

    Michael Kracht

  • Research Location

    Germany

  • Lead Research Institution

    Philipps-University Marburg and Justus-Liebig-University Giessen

  • Research Priority Alignment

    N/A

  • Research Category

    N/A

  • Research Subcategory

    N/A

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Part of the Collaborative Research Centre CRC 1021 "RNA Viruses: RNA Metabolism, Host Response and Pathogenesis" at Philipps-Universität Marburg with Justus-Liebig-Universität Giessen, funded since 2013. The molecular mechanisms affecting individual steps of gene expression in coronavirus- infected cells are largely unknown. By exploiting a comprehensive set of transcriptome, ChIP-seq and proteomics data we will work out the functional relevance of the most strongly regulated (i) non-coding genomic regions, (ii) signaling proteins (transcription factors, mRNA decay factors, protein kinases) and (iii) protein modifications. This analysis will generate new mechanistic insight into the CoV-regulated signaling network that controls HCoV-229E replication or the expression of host cell gene