Phosphorylation-dependent regulation of the RNA metabolism in the host response to coronavirus infection

Part of the Collaborative Research Centre CRC 1021 "RNA Viruses: RNA Metabolism, Host Response and Pathogenesis" at Philipps-Universität Marburg with Justus-Liebig-Universität Giessen, funded since 2013. The molecular mechanisms affecting individual steps of gene expression in coronavirus- infected cells are largely unknown. By exploiting a comprehensive set of transcriptome, ChIP-seq and proteomics data we will work out the functional relevance of the most strongly regulated (i) non-coding genomic regions, (ii) signaling proteins (transcription factors, mRNA decay factors, protein kinases) and (iii) protein modifications. This analysis will generate new mechanistic insight into the CoV-regulated signaling network that controls HCoV-229E replication or the expression of host cell gene