OX79 Coronavirus Record Linkage Project

Grant number: 221514/Z/20/Z

Grant search

Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2021
  • Known Financial Commitments (USD)

    $321,855.69
  • Funder

    Wellcome Trust
  • Principle Investigator

    Pending
  • Research Location

    United Kingdom, Europe
  • Lead Research Institution

    University of Oxford
  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Prognostic factors for disease severity

  • Special Interest Tags

    Gender

  • Study Subject

    Clinical

  • Clinical Trial Details

    Unspecified

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Other

  • Occupations of Interest

    Unspecified

Abstract

We propose to undertake large scale data linkage between critical and primary care for patients with severe COVID-19 disease to: • allow rapid assessment of the effects of routine medications and • Understand the detailed effects of comorbidities on outcomes. Assessing the effects of routine medications on COVID is urgent for two reasons. Firstly, some medications (for example, angiotensin converting enzyme inhibitors (ACEi), angiotension II receptor blockers (ARBs), thiazolidinediones and non-steroidal antiinflammatory drugs (NSAIDS)) have been implicated in causing severe disease. As a result patients and clinicians are unclear about whether they should be continued. Secondly, it has been suggested that some routine medications (for example corticosteroids and hydroxychloroquine) may treat or ameliorate infection. In both cases, the evidence underlying effects is limited. Detailed knowledge of how different comorbidities affect outcome once admitted to an ICU is critical to optimum intensive care practice during the course of the pandemic.

Publicationslinked via Europe PMC

Last Updated:39 minutes ago

View all publications at Europe PMC

Preexisting Neuropsychiatric Conditions and Associated Risk of Severe COVID-19 Infection and Other Acute Respiratory Infections.

Neuropsychiatric Ramifications of Severe COVID-19 and Other Severe Acute Respiratory Infections.

Association between smoking, e-cigarette use and severe COVID-19: a cohort study.

NHS Health Checks: an observational study of equity and outcomes 2009-2017.

Association between pre-existing respiratory disease and its treatment, and severe COVID-19: a population cohort study.

Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study.

NHS Health Checks for people with mental ill-health 2013-2017: an observational study.

Analysis of severe outcomes associated with the SARS-CoV-2 Variant of Concern 202012/01 in England using ICNARC Case Mix Programme and QResearch databases

Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people.