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PDZ domain host proteins targeted by SARS-Cov_2 during infection]

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Known Financial Commitments (USD)

    $167,994

  • Funder

    ANR

  • Principal Investigator

    Nicolas WOLFF

  • Research Location

    France

  • Lead Research Institution

    Institut Pasteur / Paris

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The PDZCov2 project, coordinated by Nicolas Wolff (Institut Pasteur / Paris), aims to identify the interactions between the envelope protein E of SARS-CoV and human cellular proteins with PDZ domain, to characterize them and to clarify their biological role in cells. infected with SARS-CoV-2. The identification of cellular partners of protein E and the structural characterization of their interactions will be useful results to help design molecules capable of dissociating such complexes, thus providing potential antiviral candidates.