Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: the COVID-HEART study

  • Funded by Department of Health and Social Care / National Institute for Health and Care Research (DHSC-NIHR), UK Research and Innovation (UKRI)
  • Total publications:13 publications

Grant number: MC_PC_20014

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2021
  • Known Financial Commitments (USD)

    $507,687.88
  • Funder

    Department of Health and Social Care / National Institute for Health and Care Research (DHSC-NIHR), UK Research and Innovation (UKRI)
  • Principle Investigator

    Pending
  • Research Location

    United Kingdom, Europe
  • Lead Research Institution

    Leeds Teaching Hospitals NHS trust
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Diagnostics

  • Special Interest Tags

    Gender

  • Study Subject

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

COVID-HEART is a large UK multi-centre consortium committed to work together to answer a set of unique and important clinical questions. The bid is backed by the major UK professional cardiovascular societies and the NIHR-BHF Cardiovascular Partnership have designated it as a "COVID-19 Cardiovascular Disease UK Flagship Project" (see attached letter). Whilst up to 20% of hospitalised COVID-19 patients may have cardiac injury based on serum troponin (and associated with high mortality), this is non-specific and can relate to pericarditis, myocarditis, acute coronary syndromes, acute heart failure, arrhythmias, or simply hypoxia/sepsis/shock. Cardiovascular magnetic resonance (CMR) can make a specific diagnosis and is recommended in European Society of Cardiology practice guidelines. We will use CMR to determine 1) the UK prevalence of acute myocardial injury/myocarditis secondary to COVID-19 and the severity of presentation; 2) how clinical outcomes associate with recognised risk factors for mortality such as age, sex, ethnicity and comorbidities (diabetes, hypertension, heart failure, and coronary/peripheral vascular disease; 3) if there are differences in myocardial recovery at 6 months dependent on demographics, genetics and comorbidities, and how this impacts on patient quality of life and functional capacity; 4) if we can improve the ECG diagnosis of myocarditis minimising the requirement for invasive cardiac investigations. Ethics approval has been granted for clinical CMR scans enabling us to start quickly, and if funded we would extend this approval to include the additional research scans, other investigations, patient reported outcome measures and follow-up as described below.

Publicationslinked via Europe PMC

Last Updated:39 minutes ago

View all publications at Europe PMC

Invasive Assessments For Coronary Vasomotor Disorders: Current State of the Art Methods Collection.

Myocardial Involvement After Hospitalization for COVID-19 Complicated by Troponin Elevation: A Prospective, Multicenter, Observational Study.

Coronary physiological assessment in the catheter laboratory: haemodynamics, clinical assessment and future perspectives.

Coronary blood flow and severe aortic stenosis.

Right ventricular free wall longitudinal strain is independently associated with mortality in mechanically ventilated patients with COVID-19.

Cardiovascular magnetic resonance imaging and spectroscopy in clinical long-COVID-19 syndrome: a prospective case-control study.

Strengths and limitations of meta-analyses.

Right ventricular dysfunction in patients with COVID-19 pneumonitis whose lungs are mechanically ventilated: a multicentre prospective cohort study.

Interventional Diagnostic Procedure: a Practical Guide for the Assessment of Coronary Vascular Function.