Rapid Prototyping and Deployment of a Therapeutic Pan-Coronavirus Fusogenix DNA Vaccine Engineered to Eliminate ADE

  • Funded by Canadian Institutes of Health Research (CIHR), Research Nova Scotia
  • Total publications:1 publications

Grant number: 172710

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2020
  • Known Financial Commitments (USD)

    $3,131,250
  • Funder

    Canadian Institutes of Health Research (CIHR), Research Nova Scotia
  • Principle Investigator

    Pending
  • Research Location

    Canada, Americas
  • Lead Research Institution

    University of Alberta Experimental Oncology
  • Research Category

    Vaccines research, development and implementation

  • Research Subcategory

    Pre-clinical studies

  • Special Interest Tags

    Gender

  • Study Subject

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

In this project, this team will rapidly develop, validate and clinically evaluate a novel DNA Vaccine against COVID-19 utilizing well-validated Fusogenix proteolipid vehicle (PLV) intracellular delivery platform. The use of a plasmid DNA vaccine will allow us to utilize multiple epitopes from key immunogenic SARS-COV-2 proteins, generating protection against structural components of the novel coronavirus, which should not only protect against viral entry but provide a robust cell-based response during active infection. Working with an international multi-disciplinary team including investigators at University of Alberta, Dalhousie University, Entos Pharmaceuticals, VIDO, EpiVax, Virscio and a pharmaceutical partner, we will rapidly prototype, validate and clinically evaluate a pan-coronavirus DNA vaccine. Clinical trials will be initiated at the Canadian center for Vaccinology in Halifax within 8 weeks of project initiation, with the goal of a commercial release within one year.

Publicationslinked via Europe PMC

Last Updated:39 minutes ago

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Eigenfunction martingale estimating functions and filtered data for drift estimation of discretely observed multiscale diffusions.