Identification and validation of nutraceuticals that prevent SARS-CoV-2 infection

COVID-19 is a significant global health burden and new strategies are needed to reduce the risk of SARS-CoV-2 infection. In this project, we will test nutraceuticals (i.e., bioactive molecules from food) to see if they bind to and inhibit the entry of the virus into the cell. Interestingly, using computer modeling, nutraceuticals have been predicted to bind to SARS-CoV-2. In aim 1, we will directly test if nutraceuticals bind to the virus and prevent its entry into the cell. In aim 2, we will determine the dosing strategy (i.e., how much and how often you need to take the supplement so that the nutraceutical can get to the lungs and bind to the virus) to provide maximal protection. In aim 3, we will test the nutraceuticals anti-viral effects in mouse models. Through this work, we will directly determine which nutraceutical can bind to and inhibit SARS-CoV-2 infection and provide a new approach to reducing the risk of infection.