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CHARACTERIZATION OF INNATE AND ADAPTIVE IMMUNE RESPONSES INDUCED BY DIFFERENT HUMAN CORONAVIRUSES IN HUMAN PRIMARY SYSTEMS

  • Funded by National Institutes of Health (NIH)
  • Total publications:0 publications

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2020
    2021

  • Known Financial Commitments (USD)

    $423,750

  • Funder

    National Institutes of Health (NIH)

  • Principal Investigator

    ANA FERNANDEZ-SESMA

  • Research Location

    United States of America

  • Lead Research Institution

    ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

ABSTRACTThrough comparative analysis, different coronaviruses, including the novel SARS-CoV-2 andhuman seasonal coronaviruses hCoV-OC43 and hCoV-NL63 will be used to unveil both theirsimilarities and differences in cellular susceptibility and permissiveness, innate immuneresponses, and immune modulatory potential in primary human cell systems including monocytederived dendritic cells (MDDCs), normal human bronchial epithelial cells (NHBEs), and an exvivo tonsil histoculture (HC) system. We will use state of the art techniques to analyze toseresponses intracellularly and extracellularly. Our group specializes in the manipulation ofprimary human cell systems and investigating both innate immune responses to viral infectionas well as viral antagonism of innate immune sensing. As such we are uniquely positioned torespond to this new public health threat and provide critical information regarding the molecularbiology of SARS-CoV-2.