CHARACTERIZATION OF INNATE AND ADAPTIVE IMMUNE RESPONSES INDUCED BY DIFFERENT HUMAN CORONAVIRUSES IN HUMAN PRIMARY SYSTEMS
- Funded by National Institutes of Health (NIH)
- Total publications:0 publications
Grant number: unknown
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Key facts
Disease
COVID-19Start & end year
20202021Known Financial Commitments (USD)
$423,750Funder
National Institutes of Health (NIH)Principal Investigator
ANA FERNANDEZ-SESMAResearch Location
United States of AmericaLead Research Institution
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAIResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Immunity
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
ABSTRACTThrough comparative analysis, different coronaviruses, including the novel SARS-CoV-2 andhuman seasonal coronaviruses hCoV-OC43 and hCoV-NL63 will be used to unveil both theirsimilarities and differences in cellular susceptibility and permissiveness, innate immuneresponses, and immune modulatory potential in primary human cell systems including monocytederived dendritic cells (MDDCs), normal human bronchial epithelial cells (NHBEs), and an exvivo tonsil histoculture (HC) system. We will use state of the art techniques to analyze toseresponses intracellularly and extracellularly. Our group specializes in the manipulation ofprimary human cell systems and investigating both innate immune responses to viral infectionas well as viral antagonism of innate immune sensing. As such we are uniquely positioned torespond to this new public health threat and provide critical information regarding the molecularbiology of SARS-CoV-2.