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Covid-related changes in Taste Epithelium

  • Funded by National Institutes of Health (NIH)
  • Total publications:0 publications

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2020
    2021

  • Known Financial Commitments (USD)

    $191,384

  • Funder

    National Institutes of Health (NIH)

  • Principal Investigator

    Pending

  • Research Location

    United States of America, Germany

  • Lead Research Institution

    University of Colorado Denver

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Disease pathogenesis

  • Special Interest Tags

    Data Management and Data Sharing

  • Study Subject

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

PROJECT SUMMARYDisruption of the sense of taste is a common feature of COVID-19. The proposed supplement will investigatepotential histopathological changes in taste buds and the surrounding epithelium of the tongue in patients whohave lost their sense of taste during COVID-19. Biopsies of fungiform papillae will be obtained from a tastecenter in Germany which shall conduct psychophysical testing prior to sampling 4 fungiform papillae frompatients recovering from COVID-19 - either with or without taste loss. We will analyze these samplesmolecularly and histologically to test for presence of residual virus and for changes in taste bud number,morphology or cellular composition.