COVID-19 and ischemic stroke - How to tame a dozing monster
- Funded by Netherlands Organisation for Health Research and Development (ZonMW)
- Total publications:0 publications
Grant number: 1.043E+13
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Key facts
Disease
COVID-19Start & end year
20202022Known Financial Commitments (USD)
$549,036.3Funder
Netherlands Organisation for Health Research and Development (ZonMW)Principal Investigator
PendingResearch Location
NetherlandsLead Research Institution
Leiden University Medical CenterResearch Priority Alignment
N/A
Research Category
Clinical characterisation and management
Research Subcategory
Disease pathogenesis
Special Interest Tags
N/A
Study Subject
Clinical
Clinical Trial Details
Not applicable
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified
Abstract
Project description Patients with COVID-19 pneumonia, especially when admitted to intensive care, may develop thrombotic complications that may contribute to a more serious course of COVID-19 pneumonia. Pulmonary embolism (clot in the lung) is the most common complication, but stroke can also occur. The hypothesis in this study is that these strokes may be caused by coagulation activation and inflammation of the arteries, or that they are the result of a blood clot entering the brain vessels from the leg or pelvic vessels through an open connection between the right and left sides of the heart. ends up. Research and expected outcomes In three work packages, knowledge is obtained about: an accurate estimate of the occurrence of ischemic stroke in COVID-19 IC patients. the causes and consequences of strokes based on imaging studies and lab tests. the optimal prevention of strokes by examining the effect of different treatments.