COVID-19 and ischemic stroke - How to tame a dozing monster

  • Funded by Netherlands Organisation for Health Research and Development (ZonMW)
  • Total publications:0 publications

Grant number: 1.043E+13

Grant search

Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2022
  • Known Financial Commitments (USD)

    $549,036.3
  • Funder

    Netherlands Organisation for Health Research and Development (ZonMW)
  • Principle Investigator

    Pending
  • Research Location

    Netherlands, Europe
  • Lead Research Institution

    Leiden University Medical Center
  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Disease pathogenesis

  • Special Interest Tags

    Gender

  • Study Subject

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Project description Patients with COVID-19 pneumonia, especially when admitted to intensive care, may develop thrombotic complications that may contribute to a more serious course of COVID-19 pneumonia. Pulmonary embolism (clot in the lung) is the most common complication, but stroke can also occur. The hypothesis in this study is that these strokes may be caused by coagulation activation and inflammation of the arteries, or that they are the result of a blood clot entering the brain vessels from the leg or pelvic vessels through an open connection between the right and left sides of the heart. ends up. Research and expected outcomes In three work packages, knowledge is obtained about: an accurate estimate of the occurrence of ischemic stroke in COVID-19 IC patients. the causes and consequences of strokes based on imaging studies and lab tests. the optimal prevention of strokes by examining the effect of different treatments.