Ex vivo models to study tissue-specific features of SARS-CoV-2 infection
- Funded by Netherlands Organisation for Health Research and Development (ZonMW)
- Total publications:3 publications
Grant number: 114025009
Grant search
Key facts
Disease
COVID-19Start & end year
20202022Known Financial Commitments (USD)
$518,980.77Funder
Netherlands Organisation for Health Research and Development (ZonMW)Principal Investigator
Dr. M NijhuisResearch Location
NetherlandsLead Research Institution
University Medical Center UtrechtResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen morphology, shedding & natural history
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
Project description Infection with coronavirus not only leads to problems in the respiratory tract, but also in other organs. However, little is known about how the coronavirus infects various organs. In this project we therefore study how the coronavirus manifests itself in different organs. In addition, the research focuses on simulating coronavirus infections in cultured miniature organs in the laboratory. In these mini-organs we can study in great detail how the coronavirus infects cells and which molecular pathways it uses for this. We hope that these human cell models can contribute to improving the diagnosis and treatment of coronavirus infection, while also reducing the use of laboratory animals.
Publicationslinked via Europe PMC
Last Updated:5 days ago
View all publications at Europe PMC