Ex vivo models to study tissue-specific features of SARS-CoV-2 infection

  • Funded by Netherlands Organisation for Health Research and Development (ZonMW)
  • Total publications:2 publications

Grant number: 114025009

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2022
  • Known Financial Commitments (USD)

    $518,980.77
  • Funder

    Netherlands Organisation for Health Research and Development (ZonMW)
  • Principle Investigator

    Pending
  • Research Location

    Netherlands, Europe
  • Lead Research Institution

    University Medical Center Utrecht
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    Gender

  • Study Subject

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Project description Infection with coronavirus not only leads to problems in the respiratory tract, but also in other organs. However, little is known about how the coronavirus infects various organs. In this project we therefore study how the coronavirus manifests itself in different organs. In addition, the research focuses on simulating coronavirus infections in cultured miniature organs in the laboratory. In these mini-organs we can study in great detail how the coronavirus infects cells and which molecular pathways it uses for this. We hope that these human cell models can contribute to improving the diagnosis and treatment of coronavirus infection, while also reducing the use of laboratory animals.

Publicationslinked via Europe PMC

Last Updated:38 minutes ago

View all publications at Europe PMC

Impaired SARS-CoV-2 specific T-cell response in patients with severe COVID-19.

In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center.