Identifying pathogenesis of COVID-19 pathology in the Dutch population and unravelling differences in pathogenetic mechanisms in high- and low-risk groups

Project description COVID-19 has a striking variation in disease severity between patients. There is so far insufficient knowledge about which processes in the tissue are the cause of this variation. This limits the development of targeted diagnostics and therapy for individual patients. Tissue studies in COVID-19 patients may change this, as the tissue can distinguish between direct virus-induced damage, out-of-control inflammation, increased coagulation, and scarring, all of which may require different treatment. need. Research and expected outcomes Within the framework of this project, the tissue available and suitable in the Netherlands from both deceased and living COVID-19 patients will be collected to be able to ask and answer these questions. The results are expected to lead to improved understanding of the variability of this disease and lead to more personalized treatment.