Identifying pathogenesis of COVID-19 pathology in the Dutch population and unravelling differences in pathogenetic mechanisms in high- and low-risk groups

  • Funded by Netherlands Organisation for Health Research and Development (ZonMW)
  • Total publications:0 publications

Grant number: 1.043E+13

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Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2022
  • Known Financial Commitments (USD)

    $526,491.36
  • Funder

    Netherlands Organisation for Health Research and Development (ZonMW)
  • Principle Investigator

    Pending
  • Research Location

    Netherlands, Europe
  • Lead Research Institution

    Erasmus Medical Center
  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Disease pathogenesis

  • Special Interest Tags

    Gender

  • Study Subject

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Project description COVID-19 has a striking variation in disease severity between patients. There is so far insufficient knowledge about which processes in the tissue are the cause of this variation. This limits the development of targeted diagnostics and therapy for individual patients. Tissue studies in COVID-19 patients may change this, as the tissue can distinguish between direct virus-induced damage, out-of-control inflammation, increased coagulation, and scarring, all of which may require different treatment. need. Research and expected outcomes Within the framework of this project, the tissue available and suitable in the Netherlands from both deceased and living COVID-19 patients will be collected to be able to ask and answer these questions. The results are expected to lead to improved understanding of the variability of this disease and lead to more personalized treatment.