Immunity against SARS-CoV-2 in immune-suppressed patients: increased risk of insufficient immunological memory or sufficient protection against re-infection?
- Funded by Netherlands Organisation for Health Research and Development (ZonMW)
- Total publications:0 publications
Grant number: 1.043E+13
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Key facts
Disease
COVID-19Start & end year
20202021Known Financial Commitments (USD)
$320,331.76Funder
Netherlands Organisation for Health Research and Development (ZonMW)Principal Investigator
Prof Dr TW KuijpersResearch Location
NetherlandsLead Research Institution
Amsterdam University Medical Center - location AMCResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Immunity
Special Interest Tags
N/A
Study Type
Clinical
Clinical Trial Details
Not applicable
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified
Abstract
Patients with autoimmune diseases often use immunosuppressive medication. The effect of these treatments on the development and maintenance of adequate immunity after a previous COVID-19 infection and on the upcoming vaccines against Covid-19 is unknown. Research and expected outcomes First of all, COVID-19 specific immunity is investigated in patients and healthy people after a previous COVID-19 infection. In the second phase, the response to a COVID-19 vaccination is compared between infected patients and healthy people. In addition, this response is compared to patients and healthy people without prior COVID-19 infection. With these results, the hope is to determine the effect of different types of immunosuppressant medications on immunity to COVID-19, so that advice can be provided on the optimal vaccination strategy in the many immunosuppressed patients. This study is a collaboration between several university centers, Sanquin Blood Supply and the RIVM (Target to B consortium, T2B).