Obesity as an amplifier of inflammation and organ injury in SARS-CoV-2 infected patients: prognostic potential and therapeutic target Thema 3:  Risicoanalyse en prognostiek

  • Funded by Netherlands Organisation for Health Research and Development (ZonMW)
  • Total publications:0 publications

Grant number: 1.043E+13

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Key facts

  • Disease

  • Start & end year

  • Known Financial Commitments (USD)

  • Funder

    Netherlands Organisation for Health Research and Development (ZonMW)
  • Principle Investigator

  • Research Location

    Netherlands, Europe
  • Lead Research Institution

    University Medical Center Groningen
  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Prognostic factors for disease severity

  • Special Interest Tags


  • Study Subject


  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment


  • Age Group


  • Vulnerable Population


  • Occupations of Interest



Project description Recent research shows that 77% of the COVID-19 patients who were treated in a Dutch Intensive Care Unit (IC) were overweight. There is some evidence that there is a positive correlation between obesity and the severity of COVID-19. Why overweight people often come to the ICU with severe symptoms of COVID-19 is not yet known. Research and expected outcomes This study investigates the underlying molecular mechanisms behind the reinforcing role of excess adipose tissue on the response of the COVID-19 patient. It is investigated exactly how excess adipose tissue contributes to the development of organ failure, especially failing lungs and kidneys. Once these mechanisms behind COVID-19-mediated organ failure are understood, new drug therapies can be developed to combat organ failure.