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Obesity as an amplifier of inflammation and organ injury in SARS-CoV-2 infected patients: prognostic potential and therapeutic target Thema 3:  Risicoanalyse en prognostiek

  • Funded by Netherlands Organisation for Health Research and Development (ZonMW)
  • Total publications:0 publications

Grant number: 1.043E+13

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2020
    2022

  • Known Financial Commitments (USD)

    $502,281.54

  • Funder

    Netherlands Organisation for Health Research and Development (ZonMW)

  • Principal Investigator

    Dr. J Moser

  • Research Location

    Netherlands

  • Lead Research Institution

    University Medical Center Groningen

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Prognostic factors for disease severity

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Other

  • Occupations of Interest

    Unspecified

Abstract

Project description Recent research shows that 77% of the COVID-19 patients who were treated in a Dutch Intensive Care Unit (IC) were overweight. There is some evidence that there is a positive correlation between obesity and the severity of COVID-19. Why overweight people often come to the ICU with severe symptoms of COVID-19 is not yet known. Research and expected outcomes This study investigates the underlying molecular mechanisms behind the reinforcing role of excess adipose tissue on the response of the COVID-19 patient. It is investigated exactly how excess adipose tissue contributes to the development of organ failure, especially failing lungs and kidneys. Once these mechanisms behind COVID-19-mediated organ failure are understood, new drug therapies can be developed to combat organ failure.