Serologic surveillance of SARS-CoV-2 during the 2020 pandemic in exposed and unexposed healthcare workers in a tertiary care hospital in Amsterdam (S3 study)

Project description In the S3 study, three groups of hospital employees are followed within the Amsterdam UMC during the COVID pandemic. These are doctors and nurses in the COVID wards, doctors and nurses in the non-COVID wards and employees without direct patient contact. Periodically it is checked whether these employees have produced antibodies against SARS-CoV-2 in order to determine whether healthcare employees are infected more often and, if so, which employees are at greatest risk. Questionnaires are used to identify whether certain exposure risks in the workplace (eg in which department someone works, whether the correct protective measures are followed, whether colleagues have had complaints, etc.) are associated with a higher chance of infection. In addition, it is being investigated whether having antibodies against other coronaviruses that frequently cause a 'common' cold in the Netherlands has an influence on the course (complaints, antibody response, etc.) of SARS-CoV-2. In the S3 study, three groups of hospital employees are followed within the Amsterdam UMC during the COVID pandemic. These are doctors and nurses in the COVID wards, doctors and nurses in the non-COVID wards and employees without direct patient contact. Periodically it is checked whether these employees have produced antibodies against SARS-CoV-2 in order to determine whether healthcare employees are infected more often and, if so, which employees are at greatest risk. Questionnaires are used to identify whether certain exposure risks in the workplace (eg in which department someone works, whether the correct protective measures are followed, whether colleagues have had complaints, etc.) are associated with a higher chance of infection. In addition, it is being investigated whether having antibodies against other coronaviruses that frequently cause a 'common' cold in the Netherlands has an influence on the course (complaints, antibody response, etc.) of SARS-CoV-2.