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Structure-guided design of therapeutics and antibodies against COVID-19 [Funder: Genome BC]

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    Other Funders (Canada)

  • Principal Investigator

    Dr Sriram Subramaniam Sriram Subramaniam

  • Research Location

    Canada

  • Lead Research Institution

    University of British Columbia

  • Research Priority Alignment

    N/A

  • Research Category

    Therapeutics research, development and implementation

  • Research Subcategory

    Pre-clinical studies

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Finding an effective vaccine to slow the spread of SARS-CoV-2 as well as a therapy to treat symptoms of the disease is of the highest priority and is being pursued globally. A number of local and international companies are leading efforts to develop antibody-based therapies to prevent and treat COVID-19. This project will take "snapshots" of how the most promising antibody therapies, identified from patients who have recovered from the virus, bind to the viral surface using a powerful imaging technique known as cryo-electron microscopy. The project team are world experts in deploying this technique, and their goal will be to take a "snapshot" per week of each antibody bound to the surface of the virus. These microscopy pictures will provide information on how to improve the potency of the therapeutics and will also allow the team to identify the most potent antibody candidates as early as possible.