SUrfaCe Characteristics Enabled StrategieS against virus transmission (SUCCESS)

  • Funded by UK Research and Innovation (UKRI)
  • Total publications:7 publications

Grant number: EP/V029762/1

Grant search

Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2022
  • Known Financial Commitments (USD)

    $828,886.92
  • Funder

    UK Research and Innovation (UKRI)
  • Principle Investigator

    Pending
  • Research Location

    United Kingdom, Europe
  • Lead Research Institution

    University of Birmingham
  • Research Category

    Infection prevention and control

  • Research Subcategory

    Barriers, PPE, environmental, animal and vector control measures

  • Special Interest Tags

    Gender

  • Study Subject

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

We propose to mitigate the transmission of COVID-19 between humans by development of antiviral formulated products. It will be delivered via additives in domestic formulated products, e.g. spray or aerosol, or integrated with current manufacturing processes, forming an invisible and long-lasting film of sub-micron thickness. Unlike disinfectants, formulations will be designed to both capture the aerosol droplets and inactivate the virus. Our first priority is to establish a mechanistic understanding of the interactions between aerosol droplets (or pure virus particles) and surfaces, which will inform possible antiviral mechanisms while providing a set of fundamental and coherent design principles for antiviral surfaces. Two technology platforms will be pursued to leverage the expertise and capability of our industrial partners. Polymer additives with controlled chemistry and molecular architecture will be explored to generate molecular films that facilitate disruption of aerosolised droplets and which may rupture the viral envelope or interfere adversely with key viral proteins and or genetic material. Proposed nanocellulose additives will confer additional benefits in terms of providing a porous structure designed to wick and absorb any protective mucus present. In parallel, hybrid polymer technology will be developed, employing reactive oxygen-producing copper nanoparticles coupled with flavin dyes that produce singlet oxygen species known to deactivate viruses when irradiated with light of the appropriate wavelength. Upon satisfactory antiviral testing results, promising design/formulation will be recommended based on their processability, suitability for end-applications, and environmental impact. Industrial partners with substantial experience in formulation will carry out pilot-scale production and full- scale manufacturing subsequently.

Publicationslinked via Europe PMC

Last Updated:38 minutes ago

View all publications at Europe PMC

Microwave-enhanced antibacterial activity of polydopamine-silver hybrid nanoparticles.

Porous Cellulose Thin Films as Sustainable and Effective Antimicrobial Surface Coatings.

Quantifying the Mechanical Properties of Yeast Candida albicans Using Atomic Force Microscopy-based Force Spectroscopy.

Tuning riboflavin derivatives for photodynamic inactivation of pathogens.

Characteristics of respiratory microdroplet nuclei on common substrates.

Molecular Understanding of Fouling Induction and Removal: Effect of the Interface Temperature on Milk Deposits.

Tribocorrosion behaviour of pure titanium in bovine serum albumin solution: A multiscale study.