Mechanism of the macrophage response to COVID-19 in humans, with the intent of understanding the cytokine storm

  • Funded by UK Research and Innovation (UKRI)
  • Total publications:0 publications

Grant number: C19-IUC-305

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Key facts

  • Disease

    COVID-19
  • Funder

    UK Research and Innovation (UKRI)
  • Principle Investigator

    Pending
  • Research Location

    United Kingdom, Europe
  • Lead Research Institution

    MRC Centre for Reproductive Health at the University of Edinburgh
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    Gender

  • Study Subject

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

A major cause of death from COVID 19 is due to a 'cytokine storm'; an overreaction of the body's immune system including white blood cells called macrophages. This project seeks to understand whether COVID19 directly interacts with human macrophages to induce a strong inflammatory response and if so, what are the mechanisms behind this response. The aim is to then define intervention strategies targeted at macrophages to mitigate the response in humans.