Mechanism of the macrophage response to COVID-19 in humans, with the intent of understanding the cytokine storm
- Funded by UK Research and Innovation (UKRI)
- Total publications:0 publications
Grant number: C19-IUC-305
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Key facts
Disease
COVID-19Funder
UK Research and Innovation (UKRI)Principal Investigator
PendingResearch Location
United KingdomLead Research Institution
MRC Centre for Reproductive Health at the University of EdinburghResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen morphology, shedding & natural history
Special Interest Tags
N/A
Study Subject
Unspecified
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified
Abstract
A major cause of death from COVID 19 is due to a 'cytokine storm'; an overreaction of the body's immune system including white blood cells called macrophages. This project seeks to understand whether COVID19 directly interacts with human macrophages to induce a strong inflammatory response and if so, what are the mechanisms behind this response. The aim is to then define intervention strategies targeted at macrophages to mitigate the response in humans.