Chemical biology tools for investigating the chemistry of cellular redox stress

  • Funded by UK Research and Innovation (UKRI)
  • Total publications:27 publications

Grant number: EP/S019901/1

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Key facts

  • Disease

    COVID-19
  • Funder

    UK Research and Innovation (UKRI)
  • Principle Investigator

    Pending
  • Research Location

    United Kingdom, Europe
  • Lead Research Institution

    University of Oxford
  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Prognostic factors for disease severity

  • Special Interest Tags

    Gender

  • Study Subject

    Not applicable

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

The primary cause of death resulting from infection with (SARS-CoV-2) is pneumonia, which causes acute respiratory distress syndrome (ARDS). Studies have shown that 14% of SARS-CoV-2-related cases of pneumonia are severe and ≈5% of infected patients require intensive care. The disease is fatal in around 60% of severe and critically ill patients, with evidence showing that hypoxemia (low SpO2) is linked to a fatal outcome. It is currently unclear what leads patients to develop these severe symptoms, which can often occur after the patients is seemingly recovering. Given the limited availability of intensive care beds and oxygen treatment, the identification of simple and reliable predictive biomarkers in hospitalised COVID-19 patients is essential to allow prioritisation of treatment. The tools that we will develop will allow accurate determination of SpO2 and CO2 levels simultaneously, allowing more informed and effective clinical decisions to be made. These tools will also allow the real-time monitoring of oxygen therapy, enabling clinicians to determine if this treatment is being used effectively.

Publicationslinked via Europe PMC

Last Updated:38 minutes ago

View all publications at Europe PMC

Correction to "Synthesis, Characterization, and Computational Studies on Gallium(III) and Iron(III) Complexes with a Pentadentate Macrocyclic bis-Phosphinate Chelator and Their Investigation As Molecular Scaffolds for 18F Binding".

Coupling Photoresponsive Transmembrane Ion Transport with Transition Metal Catalysis.

Synthesis, Characterization, and Computational Studies on Gallium(III) and Iron(III) Complexes with a Pentadentate Macrocyclic bis-Phosphinate Chelator and Their Investigation As Molecular Scaffolds for 18F Binding.

The chicken chorioallantoic membrane as a low-cost, high-throughput model for cancer imaging.

Oxali(IV)Fluors: Fluorescence Responsive Oxaliplatin(IV) Complexes Identify a Hypoxia-Dependent Reduction in Cancer Cells.

Radiometal-Labeled Photoactivatable Pt(IV) Anticancer Complex for Theranostic Phototherapy.

Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models.

Two Color Imaging of Different Hypoxia Levels in Cancer Cells.

Synthesis and anti-microbial activity of a new series of bis(diphosphine) rhenium(V) dioxo complexes.