The role of antihypertensive drugs in Covid-19

Key facts

Disease
COVID-19
Known Financial Commitments (USD)
$428,400
Funder
FWF
Principal Investigator
Oliver Langer
Research Location
Austria
Lead Research Institution
Department of Clinical Pharmacology, Medical University of Vienna
Research Priority Alignment
N/A

Research Category
Therapeutics research, development and implementation
Research Subcategory
Pre-clinical studies
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified

Abstract

Do antihypertensive drugs have an impact on SARS-CoV-2 infection? Since the pandemic began, researchers have been using a variety of methods in an attempt to definitively determine the role of the ACE2 enzyme, but so far without success. This enzyme is of interest because it allows the coronavirus to enter and infect healthy cells. Pharmacist Oliver Langer and his group plan to use the FWF urgent funding to develop a method that can determine the concentration of ACE2 in tissue using positron emission tomography (PET) with a radiolabelled substance, thus enabling us to better assess the impact of antihypertensives. The method and the results derived from it will make an important contribution to the development of new COVID-19 drugs.

Publicationslinked via Europe PMC

Last Updated:4 hours ago

View all publications at Europe PMC

Developing injury and illness epidemiology and surveillance in cycling (PhD Academy Award).

Effects of Hand-Rearing and Group Size on Chimpanzee (Pan troglodytes) Social Competence in Captivity.

Revisiting Spirituality in Physical Therapy Practice: Perceptions of US Practitioners.

Aflibercept for Wet Age-Related Macular Degeneration: A Prospective, Randomized Trial Comparing Treat-And-Extend and Fixed Bimonthly Dosing.

The Concentration and Duration of Lipopolysaccharide Stimulation Produce Different Cytokine Responses in an Ex Vivo Whole Blood Model in Horses.

History of Shrimp Farming and the Main Viral and Bacterial Diseases in Mexico.

Identification of Risk Factors in Patients with Recurrent Cystitis May Improve Individualized Management.

ISApl4, a New IS1595 Family Insertion Sequence Forming a Novel Pseudo-Compound Transposon That Confers Antimicrobial Multidrug Resistance in Actinobacillus pleuropneumoniae.