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A ZEBRAFISH MODEL TO STUDY SARS-COV-2 NEUROINVASION (NeuroCoVid project)

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:0 publications

Grant number: Unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Funder

    Institut Pasteur International Network (IPIN)

  • Research Location

    N/A

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Disease models

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Invasion of the central nervous system, possibly via the olfactory nerve, is suspected to play a role in respiratory failure of Covid-19 patients. This project aims to test SARS-CoV- 2 neuroinvasiveness in vivo in a zebrafish model. The zebrafish larva allows easy visualization of the entire nervous system in vivo or with whole mount fixed samples. It could provide a cheap, genetically tractable model to analyze viruss dissemination in its host and effect of antiviral drugs.