DECIPHERING THE VIRUS INTERACTIONS WITH THE ENTRY RECEPTORS IN HUMAN CELLS, AND THEIR POTENTIAL INHIBITION (DSAC project)

  • Funded by Institut Pasteur International Network (IPIN)
  • Total publications:240 publications

Grant number: Unknown

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Key facts

  • Disease

    COVID-19
  • Funder

    Institut Pasteur International Network (IPIN)
  • Principal Investigator

    N/A

  • Research Location

    N/A
  • Lead Research Institution

    N/A
  • Research Priority Alignment

    N/A
  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Researchers will develop and employ a workflow that combines cryogenic light and electron microscopy imaging modalities with computational analysis and data mining to determine high-resolution in-situ structural images of the virus-spike interactions with cell receptors and with the antibodies that abrogate their cell entry. These studies will provide a blueprint for the design of vaccines and therapeutics.

Publicationslinked via Europe PMC

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View all publications at Europe PMC

Dysregulated Alternative Splicing in Breast Cancer Subtypes of RIF1 and Other Transcripts.

Development and Validation of the Intimate Partner Violence Workplace Disruptions Assessment (IPV-WDA).

Elucidating directed neural dynamics of scene construction across memory and imagination

Implementing a Novel Resident-Led Peer Support Program for Emergency Medicine Resident Physicians.

Cross-Activity Analysis of CRISPR/Cas9 Editing in Gene Families of <i>Solanum lycopersicum</i> Detected by Long-Read Sequencing.

Creating health systems citizens: enhanced professional identity formation through a para-curricular distinction track in health systems transformation and leadership.

A Comparison of Clinical Diagnostic Classification Criteria Used in Longitudinal Cohort Studies of the Alzheimer's Disease Continuum: A Systematic Review.

Identification and Characterization of a Rare Exon 22 Duplication in <i>CFTR</i> in Two Families.

Structural Rearrangement in Cyclic Cu(II) Pyridyltriazole Complexes: Oxidation of Dabco to Oxalate and CO<sub>2</sub> Conversion to Carbonate.